UK Plans Landmark Study on Puberty-Blockers’ Effect on Children With Gender Distress: Critics Express Doubt It Will Advance the Weak Evidence Base

The stakes of this hotly anticipated trial have only heightened since President Trump’s second term has posed an existential threat to such research in the United States.

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The logo of the National Health Service is seen on the exterior of St Thomas' Hospital on March 13, 2025 at London, England. Leon Neal/Getty Images

The United Kingdom will spend $13.9 million to study the impacts of puberty blockers on minors experiencing gender-related distress. The U.K.’s National Health Service earlier this month announced its plan to invest in much-anticipated research into the controversial treatments, for which there remains insufficient data, per an NHS-commissioned report called the Cass Review. The study still needs to pass muster with an NHS ethics board.  

The stakes of Britain’s study have only intensified following PresidentTrump’s return to power, which poses an existential threat to the American branch of pediatric gender medicine, a beleaguered field that provides medical treatments and surgeries to minors to change their sex characteristics. Advocates of the treatments refer to these interventions as gender-affirming care, while the White House, in a recent executive order, labeled them as “chemical and surgical mutilation.” 

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